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Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.

Tacconi EM(1), Badie S(1), De Gregoriis G(1), Reislander T(1), Lai X(1), Porru M(2), Folio C(1), Moore J(3), Kopp A(4), Baguna Torres J(5), Sneddon D(5), Green M(3), Dedic S(1), Lee JW(1), Batra AS(6), Rueda OM(6), Bruna A(6), Leonetti C(2), Caldas C(6), Cornelissen B(5), Brino L(4), Ryan A(3), Biroccio A(2), Tarsounas M(1).

EMBO Mol Med 2019; 11(7):e9982

Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets.

Verrier ER(1), Weiss A(2), Bach C(1), Heydmann L(1), Turon-Lagot V(1), Kopp A(2), El Saghire H(1), Crouchet E(1), Pessaux P(1)(3), Garcia T(4), Pale P(4), Zeisel MB(1), Sureau C(5), Schuster C(1), Brino L(2), Baumert TF(1)(3)(6).

Gut 2019; (0):0

Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on EREG-Driven Oncogenic Addiction.

Job S(1), Reynies A(2), Heller B(3), Weiss A(4), Guerin E(5)(6), Macabre C(7)(8), Ledrappier S(9)(10), Bour C(11)(12), Wasylyk C(13), Etienne-Selloum N(14)(15), Brino L(16), Gaiddon C(17), Wasylyk B(18), Jung AC(19)(20).

Cancers (Basel) 2019; 11(6):E795

A molecular roadmap for the emergence of early-embryonic-like cells in culture.

Rodriguez-Terrones D(1)(2), Gaume X(1)(2), Ishiuchi T(1)(3), Weiss A(2), Kopp A(2), Kruse K(4), Penning A(1), Vaquerizas JM(4), Brino L(2), Torres-Padilla ME(5)(6).

Nat Genet 2018; 50(1):106-119

Genes and Pathways Regulated by Androgens in Human Neural Cells, Potential Candidates for the Male Excess in Autism Spectrum Disorder.

Quartier A(1), Chatrousse L(2), Redin C(1), Keime C(1), Haumesser N(1), Maglott-Roth A(1), Brino L(1), Le Gras S(1), Benchoua A(2), Mandel JL(3), Piton A(4).

Biol Psychiatry 2018; 84(4):239-252

Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair.

Evangelista FM(1)(2)(3)(4), Maglott-Roth A(1)(2)(3)(4), Stierle M(1)(2)(3)(4), Brino L(1)(2)(3)(4), Soutoglou E(5)(2)(3)(4), Tora L(6)(2)(3)(4).

J Cell Biol 2018; 217(10):3382-3397

ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo.

Beilschmidt LK(1,)(2,)(3,)(4,)(5), Ollagnier de Choudens S(6,)(7,)(8), Fournier M(1,)(2,)(3,)(4), Sanakis I(9), Hograindleur MA(6,)(7,)(8,)(10), Clemancey M(7,)(8,)(10), Blondin G(7,)(8,)(10), Schmucker S(1,)(2,)(3,)(4,)(5), Eisenmann A(1,)(2,)(3,)(4,)(5), Weiss A(1,)(2,)(3,)(4), Koebel P(1,)(2,)(3,)(4), Messaddeq N(1,)(2,)(3,)(4), Puccio H(1,)(2,)(3,)(4,)(5), Martelli A(1,)(2,)(3,)(4,)(5).

Nat Commun 2017; 8():15124

Transcription without XPB Establishes a Unified Helicase-Independent Mechanism of Promoter Opening in Eukaryotic Gene Expression.

Alekseev S(1), Nagy Z(1), Sandoz J(1), Weiss A(1), Egly JM(1), Le May N(1), Coin F(2).

Mol Cell 2017; 65(3):504-514

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses.

Verrier ER(1,)(2), Colpitts CC(1,)(2), Bach C(1,)(2), Heydmann L(1,)(2), Weiss A(3), Renaud M(3), Durand SC(1,)(2), Habersetzer F(4), Durantel D(5), Abou-Jaoudé G(6), López Ledesma MM(7), Felmlee DJ(1,)(2), Soumillon M(8), Croonenborghs T(9,)(10), Pochet N(9), Nassal M(11), Schuster C(1,)(2), Brino L(3), Sureau C(6), Zeisel MB(1,)(2), Baumert TF(1,)(2,)(4).

Hepatology 2016; 63(1):35-48

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin.

Tsouroula K(1), Furst A(1), Rogier M(1), Heyer V(1), Maglott-Roth A(1), Ferrand A(2), Reina-San-Martin B(3), Soutoglou E(4).

Mol Cell 2016; 63(2):293-305

Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules.

Krupina K(1), Kleiss C(1), Metzger T(1), Fournane S(1), Schmucker S(1), Hofmann K(2), Fischer B(1), Paul N(3), Porter IM(4), Raffelsberger W(5), Poch O(6), Swedlow JR(4), Brino L(1), Sumara I(7).

Dev Cell 2016; 36(1):63-78

PI4K-beta and MKNK1 are regulators of hepatitis C virus IRES-dependent translation.

Lupberger J(1,)(2), Casanova C(3), Fischer B(4), Weiss A(4), Fofana I(1,)(2), Fontaine N(1,)(2), Fujiwara T(5), Renaud M(4), Kopp A(4), Schuster C(1,)(2), Brino L(4), Baumert TF(1,)(2,)(6), Thoma C(3).

Sci Rep 2015; 5():13344

The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin.

Kalousi A(1), Hoffbeck AS(1), Selemenakis PN(2), Pinder J(3), Savage KI(4), Khanna KK(4), Brino L(1), Dellaire G(3), Gorgoulis VG(5), Soutoglou E(6).

Cell Rep 2015; 11(1):149-63

A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair.

Shahar OD(1), Kalousi A(2), Eini L(1), Fisher B(2), Weiss A(2), Darr J(1), Mazina O(3), Bramson S(4), Kupiec M(4), Eden A(1), Meshorer E(1), Mazin AV(3), Brino L(2), Goldberg M(5), Soutoglou E(6).

Nucleic Acids Res 2014; 42(9):5689-701

A small molecule screen identifies an inhibitor of DNA repair inducing the degradation of TFIIH and the chemosensitization of tumor cells to platinum.

Alekseev S(1), Ayadi M(2), Brino L(1), Egly JM(1), Larsen AK(2), Coin F(3).

Chem Biol 2014; 21(3):398-407

HRas Signal Transduction Promotes Hepatitis C Virus Cell Entry by Triggering Assembly of the Host Tetraspanin Receptor Complex.

Zona L, Lupberger J, Sidahmed-Adrar N, Thumann C, Harris HJ, Barnes A, Florentin J, Tawar RG, Xiao F, Turek M, Durand SC, Duong FH, Heim MH, Cosset FL, Hirsch I, Samuel D, Brino L, Zeisel MB, Le Naour F, McKeating JA, Baumert TF.

Cell Host Microbe 2013; 13(3):302-13

The human TREX-2 complex is stably associated with the nuclear pore basket.

Umlauf D(1), Bonnet J, Waharte F, Fournier M, Stierle M, Fischer B, Brino L, Devys D, Tora L.

J Cell Sci 2013; 126(PT 12):2656-67

Large scale genotype comparison of human papillomavirus e2-host interaction networks provides new insights for e2 molecular functions.

Muller M, Jacob Y, Jones L, Weiss A, Brino L, Chantier T, Lotteau V, Favre M, Demeret C.

PLoS Pathog 2012; 8(6):e1002761

Pyridylthiourea-grafted polyethylenimine offers an effective assistance to siRNA-mediated gene silencing in vitro and in vivo.

Creusat G(1), Thomann JS, Maglott A, Pons B, Dontenwill M, Guérin E, Frisch B, Zuber G.

J Control Release 2012; 157(3):418-26

The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response.

Lemaitre C(1), Fischer B, Kalousi A, Hoffbeck AS, Guirouilh-Barbat J, Shahar OD, Genet D, Goldberg M, Betrand P, Lopez B, Brino L, Soutoglou E.

Oncogene 2012; 31(45):4803-9

The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression.

Babbio F, Pistore C, Curti L, Castiglioni I, Kunderfranco P, Brino L, Oudet P, Seiler R, Thalman GN, Roggero E, Sarti M, Pinton S, Mello-Grand M, Chiorino G, Catapano CV, Carbone GM, Bonapace IM.

Oncogene 2012; 31(46):4878-87

Cullin 3 mediates SRC-3 ubiquitination and degradation to control the retinoic acid response.

Ferry C, Gaouar S, Fischer B, Boeglin M, Paul N, Samarut E, Piskunov A, Pankotai-Bodo G, Brino L, Rochette-Egly C.

Proc Natl Acad Sci U S A 2011; 108(51):20603-8

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

Lupberger J., Zeisel M.B., Xiao F., Thumann C., Fofana I., Zona L., Davis C., Mee C.J., Turek M., Gorke S., Royer C., Fischer B., Zahid M.N., Lavillette D., Fresquet J., Cosset F.L., Rothenberg S.M., Pietschmann T., Patel A.H., Pessaux P., Doffoel M., Raffelsberger W., Poch O., McKeating J.A., Brino L., Baumert T.F.

Nat Med 2011; 17(5):589-95

A chemical labeling strategy for proteomics under nondenaturing conditions

Budin G., Dimala M.M., Lamour V., Oudet P., Mioskowski C., Meunier S., Brino L., Wagner A.

Chembiochem 2010; 11(1):79-82

alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells.

Martinkova E(1), Maglott A, Leger DY, Bonnet D, Stiborova M, Takeda K, Martin S, Dontenwill M.

Int J Cancer 2010; 127(5):1240-8

E6 proteins from diverse papillomaviruses self-associate both in vitro and in vivo.

Zanier K(1), Ruhlmann C, Melin F, Masson M, Ould M'hamed Ould Sidi A, Bernard X, Fischer B, Brino L, Ristriani T, Rybin V, Baltzinger M, Vande Pol S, Hellwig P, Schultz P, Trave G.

J Mol Biol 2010; 396(1):90-104

Nondenaturing chemical proteomics for protein complex isolation and identification

Budin G., Moune-Dimala M., Leriche G., Saliou J.M., Papillon J., Sanglier-Cianferani S., Van Dorsselaer A., Lamour V., Brino L., Wagner A.

Chembiochem 2010; 11(17):2359-61

Optimization of the Azobenzene Scaffold for Reductive Cleavage by Dithionite; Development of an Azobenzene Cleavable Linker for Proteomic Applications

Leriche G, Budin G, Brino L, Wagner A


RReportGenerator: automatic reports from routine statistical analysis using R

Raffelsberger W., Krause Y., Moulinier L., Kieffer D., Morand A.L., Brino L., Poch O.

Bioinformatics 2008; 24(2):276-8

The PHD Domain of Np95 (mUHRF1) Is Involved in Large-Scale Reorganization of Pericentromeric Heterochromatin

Papait R., Pistore C., Grazini U., Babbio F., Cogliati S., Pecoraro D., Brino L., Morand A.L., Dechampesme A.M., Spada F., Leonhardt H., McBlane F., Oudet P., Bonapace I.M.

Mol Biol Cell 2008; 19(8):3554-3563

Localization of the yeast RNA polymerase I-specific subunits

Bischler N., Brino L., Carles C., Riva M., Tschochner H., Mallouh V., Schultz P.

Embo J 2002; 21(15):4136-44.

Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center

Brino L., Urzhumtsev A., Mousli M., Bronner C., Mitschler A., Oudet P., Moras D.

J Biol Chem 2000; 275(13):9468-75

Isoleucine 10 is essential for DNA gyrase B function in escherichia coli

Brino L., Bronner C., Oudet P., Mousli M.

Biochimie 1999; 81(10):973-80

Expression in Escherichia coli of Y5 mutant and N-terminal domain- deleted DNA gyrase B proteins affects strongly plasmid maintenance

Brino L., Mousli M., Oudet P., Weiss E.

Plasmid 1998; Vol 39, Iss 1():21-34

Expression in Escherichia coli of Y5-mutant and N-terminal domain- deleted DNA gyrase B proteins affects strongly plasmid maintenance

Brino L., Mousli M., Oudet P., Weiss E.

Plasmid 1997; Vol 38, Iss 3():188-201


Last update on Fri 09 Dec 2016


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